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Estradiol Research

Heart disease is a critical women's health crisis in Canada.

In 2019 alone, 32,271 Canadian women died from heart disease and stroke—that’s one woman every 16 minutes, and five times more than breast cancer.

While breast cancer awareness is vital, many health professionals advocate equally for women's heart health—imagine sponsoring walks and events for those affected by heart disease.

Research consistently shows bioidentical estrogen significantly protects women’s hearts, especially when started early in menopause

Estradiol and Heart Disease

Journal of the American Medical Association

 

Miller, V. T., LaRosa, J., Barnabei, V., Kessler, C., Levin, G., Smith-Roth, A., . . . Kessler, G. (1995). Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women: The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. JAMA, 273(3), 199-208.

Obstetrics and Gynecology

 

Ettinger, B., D. Friedman, G., Bush, T., & Quesenberry, C. P. (1996). Reduced mortality associated with long-term postmenopausal estrogen therapy. Obstetrics & Gynecology, 87(1), 6-12.

Maturitas

 

Grodstein, F., & Stampfer, M. J. (1998). Estrogen for women at varying risk of coronary disease. Maturitas, 30(1), 19-26. doi:10.1016/S0378-5122(98)00055-3

Circulation

McCrohon, J. A., Nakhla, S., Jessup, W., Stanley, K. K., & Celermajer, D. S. (1999). Estrogen and progesterone reduce lipid accumulation in human monocyte-derived macrophages. Circulation  , 100(23), 2319-2325.

Annals of Internal Medicine

Grodstein, F., Manson, J. E., Colditz, G. A., Willett, W. C., Speizer, F. E., & Stampfer, M. J. (2000). A prospective, observational study of postmenopausal hormone therapy and primary prevention of cardiovascular disease. Annals of Internal Medicine, 133(12), 933-941.

New England Journal of Medicine

Nabel, E. G. (2000). Coronary heart disease in women — an ounce of prevention. New England Journal of Medicine, 343(8), 572-574.

Based on findings from the Women’s Health Initiative findings

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Journal of the American Medical Association (1995)

Obstetrics and Gynecology (1996)

Maturitas (1998)

Circulation (1999)

Annals of Internal Medicine (2000)

New England Journal of Medicine (2000)

Based on findings from the Women’s Health Initiative findings

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Disclaimer: The content on this site is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. All assessments and treatment decisions are made following a full clinical evaluation and are offered within the professional scope of Nurse Practitioner practice in the province where care is provided. Our approach is designed to complement your broader health goals, whether you are working with other providers or navigating care independently.